"If he’s hurting, I'll talk to him when he gets here," Manuel said hours before the game. "I might have to change my lineup."

Manuel also admitted that Howard's left knee has been a big part of his struggles this season; Howard has just eight home runs, including just two in the last 131 at-bats.

"In Ryan's situation, to use his strength and quick swing, the back side is definitely important," Manuel said. "Push off and balance is what counts. How much it bothers him, I guess he tells us by the way he plays. I've seen where he hasn’t used his legs for quite a while."

Howard has been replaced for pinch-runners and defensive replacements at many points this season, and Manuel does not seem to know if that will change moving forward. Howard is hitting .274 with a .784 OPS, the second-lowest mark of his career. 

Cain limited the Padres to just two runs on his only two mistakes of the outing, as he allowed a pair of solo home runs. Those homers actually brought an end to a five-start homerless streak by Cain, who had allowed 13 in his first nine starts of the season.

Cain struck out a season-high 10 batters in the game while walking none over the course of seven innings of work. He threw 74 of 110 pitches for strikes, and earned a no-decision in a game the Giants would go on to win, 5-4.

Cain is 5-3 on the season with a 4.55 ERA heading into Monday's start in Los Angeles against the Dodgers. 

Crawford is currently being considered day to day, and the extent of the injury is not yet known. 

"He's very confident, you guys know that," manager Kirk Gibson told MLB.com. "He's not pouting about it, he just knows it's part of his journey to be up here and have a huge impact on our success. He's got a great attitude about it."  

Brewer tossed 3 2/3 scoreless innings in two appearances out of the bullpen for the Diamondbacks before being sent back down.

Delgado had just one rough inning, allowing two runs in the fourth. He allowed four of his eight hits in that inning, but was able to get out of it with just the two runs, and that was all the Marlins would muster in a 3-2 loss. The Diamondbacks won the game on a walk-off home run.  

Delgado allowed eight hits and no walks in seven innings of work, while striking out six batters. Despite the solid outing, Delgado may not be long for the rotation, as the team does not need a fifth starter until June 29, given the way their off-days stack up. It has not yet been decided whether Delgado will remain with the team at this point. 

 Eovaldi allowed just three hits in six innings of work, and he held the Diamondbacks to just two runs. Both runs came on a fourth-inning home run by Martin Prado that tied the game, 2-2. Eovaldi exited with the game tied and earned a no-decision, despite the quality start.

Eovaldi struck out three batters and threw 58 of 84 pitches for strikes in his first start since being shutdown with shoulder inflammation. He averaged 97.7 miles per hour with his fastball per BrooksBaseball.net, after averaging 94.1 miles per hour last season.

Eovaldi is set to make his second start Sunday in San Francisco.