| Date | Pos | Player | Injury | Status | Expected Return |
| 05/16/12 |
SP |
Vance Worley |
Elbow |
DL |
15-day DL. Out until at least late May |
| 05/19/12 |
LF |
Laynce Nix |
Calf |
DL |
15-day DL. Out until at least late June |
| 05/22/12 |
RP |
David Herndon |
Elbow |
DL |
15-day DL. Out until at least early June |
| 05/21/12 |
DH |
Jim Thome |
Back |
DL |
15-day DL. Out until at least late May |
| 05/22/12 |
RP |
Michael Stutes |
Shoulder |
DL |
15-day DL. Out until at least early June |
| 05/12/12 |
3B |
Michael Martinez |
Foot |
DL |
60-day DL. Out until at least late May |
| 20120520 |
2B |
Chase Utley |
Knee |
DL |
15-day DL. Out until at least late June |
| 05/11/12 |
RP |
Justin De Fratus |
Elbow |
DL |
60-day DL. Out until at least mid-June |
| 20120522 |
1B |
Ryan Howard |
Achilles |
DL |
15-day DL. Out until at least late June |