Mariners starter Felix Hernandez endured another rough outing as he suffered his fourth loss of the season Saturday against the Rangers.

Hernandez (5-4), who made his 11th start of the season, surrendered a run-scoring single to Jurickson Profar and a two-run double to David Murphy in the second. He served up a solo home run to Nelson Cruz in the fifth and was charged with five runs on 11 hits and one walk while striking out nine over 5 2/3 innings of work.

Hernandez has allowed 11 runs -- 10 earned -- over his last two starts (11 innings). It's the most runs he has allowed between two starts since September of 2012. He will try to get back on track Thursday at San Diego. He went 1-1 with a 4.15 ERA in his last two starts against the Padres.

Rangers closer Joe Nathan made quick work of the Mariners as he picked up his 16th save of the season Saturday night.

Nathan needed just 11 pitches as he retired the side in order to secure a 5-2 win. His ERA improved to 1.86 after making his fifth consecutive scoreless appearance. He has converted his last 17 save opportunities dating back to last season.

Rangers starter Derek Holland, who took the loss in his previous start May 19 -- allowing four runs in 4 2/3 innings -- bounced back with a quality performance as he struck out 10 and picked up his fourth win of the season Saturday night against the Mariners.

Holland allowed two unearned runs in the third inning for his only damage of the night. He retired 12 of the final 15 batters he faced and was charged with two unearned runs on four hits and three walks over 6 2/3 innings of work in a 5-2 victory.

Holland has allowed one earned run or fewer in three of his last five starts. He is scheduled to make his next start Thursday at home against Arizona. He is 1-1 with a 2.60 ERA in four starts at home.

Padres shortstop Everth Cabrera was nearly unstoppable Saturday night against the Diamondbacks, going 3 for 5 with a double, two runs, four RBI and his fourth home run of the season. He also reached on a fielding error that could have been ruled an infield single and stole his league-leading 19th base of the year.

Cabrera had never homered more than twice in a season entering 2013, hitting just five home runs in 296 career games. He's hit four homers in 48 games this season and has five multi-hit performances in his last seven games to boost his batting average to .267.

Diamondbacks starting pitcher Wade Miley struggled in Saturday's start against the Padres, surrendering seven earned runs on seven hits and one walk in just 3 2/3 innings pitched. He struck out one batter and allowed one home run.

Miley has now given up 15 earned runs in 14 2/3 innings over his last three starts, taking the loss in each to drop to 3-4 on the year. He and his 4.53 ERA are scheduled to face the Rangers in Arlington Thursday.

Padres starting pitcher Andrew Cashner secured his fourth win of the season Saturday night by holding the Diamondbacks to four earned runs on nine hits in six-plus innings of work, striking out five.

Cashner pitched to one batter in the seventh inning before being removed after 102 pitches, his highest pitch count of the year. He's 3-0 in his last four starts.

Cashner takes a 3.38 ERA into Thursday's start in San Diego against the Mariners.

Rockies second baseman Josh Rutledge was scratched by Triple-A Colorado Springs Saturday with a stomach bug.

Rutledge went 0 for 6 and struck out twice in his first game with Colorado Springs after being optioned by the Rockies earlier this week. It was Rutledge's first work in Triple-A in his career.

Athletics third baseman Josh Donaldson enjoyed his second four-hit game of May and his third of the season during Saturday's contest against the Astros.

Donaldson singled in the second, launched a solo home run in the fourth, reached on an infield single in the sixth and doubled in a run in the eighth. Donalson reached base five times and he finished 4 for 4 with a walk, two runs scored and two RBI in an 11-5 victory.

Donaldson is hitting .389 (21 for 54) with four home runs and seven RBI in his last 15 games played. He has a .322/.398/.544 slash line in 180 at-bats.

Astros catcher Jason Castro enjoyed a big night at the plate as he went deep twice and drove in three runs Saturday night against the A's.

Castro launched a pair of solo home runs off starter A.J. Griffin in the first and fourth innings and also singled in a run in the sixth. He finished 3 for 4 with two runs scored and three RBI in an 11-5 defeat. Castro is hitting .265 with six home runs and 15 RBI.

His teammate Matt Dominguez also homered twice. It was the first time two Houston teammates have had multi-home run games since July 25, 2005, when Craig Biggio and Lance Berkman each had two.

Astros third baseman Matt Dominguez continued to swing a hot bat as he homered twice Saturday against the A's.

Dominguez had solo shots in the third and seventh innings. He finished 2 for 4 with two runs scored and two RBI in an 11-5 loss. He has homered three times in his last two games since returning from a quad injury.

His teammate Jason Castro also homered twice. It was the first time two Houston teammates have had multi-home run games since July 25, 2005, when Craig Biggio and Lance Berkman each had two.