| Injuries |
| Updated | Player | Team | Status | Injury | Outlook |
| 4/1/2013 | Bellomy, Russell QB | MICH | Out | Knee | Michigan's Bellomy Tears ACL |
| 9/17/2012 | Moore, Brandon TE | MICH | Out | Knee | Michigan's Moore Won't Play Against Notre Dame |
| 9/1/2012 | Harbison, Jamel WR | MINN | Out | Knee | Minnesota's Harbison Tears ACL |
| 11/22/2012 | Jones, Marcus WR | MINN | Probable | Knee | Minnesota's Jones (Knee) Out Saturday |
| 9/13/2012 | Corbaley, Jacob TE | MTSU | Out | Knee | MTSU's Corbaley Out Three Weeks With Knee Injury |
| 9/12/2012 | Wullenwaber, Tyler WR | NEB | Out | Knee | Nebraska's Wullenwaber Hurts knee |
| 11/12/2012 | Boykin, Ryan RB | OHIO | Out | Knee | Ohio's Boykin (Knee) Out For Season |
| 9/3/2012 | Yazdani, Josiah K | OHIO | Out | Knee | Ohio's Yazdani Out Indefinitely |
| 11/1/2012 | Mostert, Raheem WR | PURDUE | Out | Knee | Purdue's Mostert (Knee) Out Another Week |
| 9/12/2012 | Carter, Montrel RB | LALAF | Out | Knee | Ragin' Cajun's Carter Out After Knee Surgery |
| 9/10/2012 | Fowler, Jalston RB | BAMA | Out | Knee | Season Over For Alabama's Fowler |
| 10/1/2012 | White, DeAndrew WR | BAMA | Out | Knee | Season Over For Alabama's White |
| 9/24/2012 | King, Tevin RB | LATECH | Out | Knee | Season Over For La Tech's King |
| 10/22/2012 | Hills, Perry QB | MD | Out | Knee | Season Over For Maryland's Hills |
| 10/15/2012 | Marquez, Bradley WR | TXTECH | Out | Knee | Season Over For Texas Tech's Marquez |
| 11/16/2012 | Montgomery, Ty WR | STNFRD | Probable | Knee | Stanford's Montgomery (Knee) To Play More But Not Start |
| 2/27/2013 | Brown, C.J. QB | MD | Out | Knee | Terps' QB Brown Limited During Spring |
| 9/5/2012 | Burnham, Bryan WR | TULSA | Out | Knee | Tulsa's Burnham Out for Season with Torn ACL |
| 10/25/2012 | Battle, Dalvin WR | MA | Out | Knee | UMass' Battle To Get Redshirt |
| 3/16/2013 | Redd, Silas RB | USC | Probable | Knee | USC's Redd Tears Meniscus |
| 9/21/2012 | Griffin, Sterling WR | SFLA | Out | Knee | USF's Griffin Has Knee Surgery |
| 10/28/2012 | Hopkins, Derrick WR | SFLA | Questionable | Knee | USF's Hopkins Injures Knee |
| 9/6/2012 | Coles, D.J. WR | VATECH | Out | Knee | Virginia Tech's Coles Has Season-Ending Knee Injury |
| 9/3/2012 | Callier, Jesse RB | WASH | Out | Knee | Washington's Callier Missing Time With Injury |
| 9/7/2012 | Simpson, Keshawn RB | WKY | Out | Knee | Western Kentucky's Simpson Out With Knee Injury |
| 9/5/2012 | Keith, Timmy WR | WMICH | Out | Knee | WMU's Keith Out for Season With Torn ACL |
| 9/25/2012 | Zordich, Michael RB | PSU | Probable | Knee | Zordich Expects To Play For Penn State |
| 11/7/2012 | Schneider, David TE | BALLST | Out | Leg | Ball State's Schneider Out Indefinitely |
| 12/15/2012 | Fluellen, David RB | TOLEDO | Questionable | Leg | Fluellen Hurt In Toledo's Bowl Game |
| 9/10/2012 | Roberson, Tre QB | IND | Out | Leg | Indiana's Roberson Out 5-6 Months With Broken leg |
