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All times are US/Eastern
| WEEK 1 | | Thursday, Sep. 10 |
| Game | Time | TV | | Tennessee 10, Pittsburgh 13 | | | | Sunday, Sep. 13 |
| Game | Time | TV | | Kansas City 24, Baltimore 38 | | | | Philadelphia 38, Carolina 10 | | | | Minnesota 34, Cleveland 20 | | | | Miami 7, Atlanta 19 | | | | Detroit 27, New Orleans 45 | | | | Jacksonville 12, Indianapolis 14 | | | | Denver 12, Cincinnati 7 | | | | Dallas 34, Tampa Bay 21 | | | | N.Y. Jets 24, Houston 7 | | | | St. Louis 0, Seattle 28 | | | | Washington 17, N.Y. Giants 23 | | | | San Francisco 20, Arizona 16 | | | | Chicago 15, Green Bay 21 | | | | Monday, Sep. 14 |
| Game | Time | TV | | Buffalo 24, New England 25 | | | | San Diego 24, Oakland 20 | | |
| WEEK 2 | | Sunday, Sep. 20 |
| Game | Time | TV | | Carolina 20, Atlanta 28 | | | | New Orleans 48, Philadelphia 22 | | | | Houston 34, Tennessee 31 | | | | Minnesota 27, Detroit 13 | | | | New England 9, N.Y. Jets 16 | | | | Arizona 31, Jacksonville 17 | | | | Oakland 13, Kansas City 10 | | | | St. Louis 7, Washington 9 | | | | Cincinnati 31, Green Bay 24 | | | | Tampa Bay 20, Buffalo 33 | | | | Seattle 10, San Francisco 23 | | | | Pittsburgh 14, Chicago 17 | | | | Cleveland 6, Denver 27 | | | | Baltimore 31, San Diego 26 | | | | N.Y. Giants 33, Dallas 31 | | | | Monday, Sep. 21 |
| Game | Time | TV | | Indianapolis 27, Miami 23 | | |
| WEEK 3 | | Sunday, Sep. 27 |
| Game | Time | TV | | Jacksonville 31, Houston 24 | | | | Tennessee 17, N.Y. Jets 24 | | | | Green Bay 36, St. Louis 17 | | | | Washington 14, Detroit 19 | | | | San Francisco 24, Minnesota 27 | | | | Atlanta 10, New England 26 | | | | N.Y. Giants 24, Tampa Bay 0 | | | | Cleveland 3, Baltimore 34 | | | | Kansas City 14, Philadelphia 34 | | | | Chicago 25, Seattle 19 | | | | New Orleans 27, Buffalo 7 | | | | Pittsburgh 20, Cincinnati 23 | | | | Denver 23, Oakland 3 | | | | Miami 13, San Diego 23 | | | | Indianapolis 31, Arizona 10 | | | | Monday, Sep. 28 |
| Game | Time | TV | | Carolina 7, Dallas 21 | | |
| WEEK 4 | | Sunday, Oct. 04 |
| Game | Time | TV | | Detroit 24, Chicago 48 | | | | Cincinnati 23, Cleveland 20 | | | | Tennessee 17, Jacksonville 37 | | | | N.Y. Giants 27, Kansas City 16 | | | | Baltimore 21, New England 27 | | | | Oakland 6, Houston 29 | | | | Tampa Bay 13, Washington 16 | | | | Seattle 17, Indianapolis 34 | | | | N.Y. Jets 10, New Orleans 24 | | | | Buffalo 10, Miami 38 | | | | St. Louis 0, San Francisco 35 | | | | Dallas 10, Denver 17 | | | | San Diego 28, Pittsburgh 38 | | | | Monday, Oct. 05 |
| Game | Time | TV | | Green Bay 23, Minnesota 30 | | | | Open date: Arizona,Atlanta,Carolina,Philadelphia |
| WEEK 5 | | Sunday, Oct. 11 |
| Game | Time | TV | | Cincinnati 17, Baltimore 14 | | | | Cleveland 6, Buffalo 3 | | | | Washington 17, Carolina 20 | | | | Pittsburgh 28, Detroit 20 | | | | Dallas 26, Kansas City 20 | | | | Oakland 7, N.Y. Giants 44 | | | | Tampa Bay 14, Philadelphia 33 | | | | Minnesota 38, St. Louis 10 | | | | Atlanta 45, San Francisco 10 | | | | New England 17, Denver 20 | | | | Jacksonville 0, Seattle 41 | | | | Houston 21, Arizona 28 | | | | Indianapolis 31, Tennessee 9 | | | | Monday, Oct. 12 |
| Game | Time | TV | | N.Y. Jets 27, Miami 31 | | | | Open date: Chicago,Green Bay,New Orleans,San Diego |
| WEEK 6 | | Sunday, Oct. 18 |
| Game | Time | TV | | Carolina 28, Tampa Bay 21 | | | | Detroit 0, Green Bay 26 | | | | St. Louis 20, Jacksonville 23 | | | | Baltimore 31, Minnesota 33 | | | | Houston 28, Cincinnati 17 | | | | Kansas City 14, Washington 6 | | | | N.Y. Giants 27, New Orleans 48 | | | | Cleveland 14, Pittsburgh 27 | | | | Philadelphia 9, Oakland 13 | | | | Arizona 27, Seattle 3 | | | | Tennessee 0, New England 59 | | | | Buffalo 16, N.Y. Jets 13 | | | | Chicago 14, Atlanta 21 | | | | Monday, Oct. 19 |
| Game | Time | TV | | Denver 34, San Diego 23 | | | | Open date: Dallas,Indianapolis,Miami,San Francisco |
| WEEK 7 | | Sunday, Oct. 25 |
| Game | Time | TV | | Indianapolis 42, St. Louis 6 | | | | New England 35, Tampa Bay 7 | | | | San Francisco 21, Houston 24 | | | | Minnesota 17, Pittsburgh 27 | | | | San Diego 37, Kansas City 7 | | | | Green Bay 31, Cleveland 3 | | | | N.Y. Jets 38, Oakland 0 | | | | Buffalo 20, Carolina 9 | | | | Atlanta 21, Dallas 37 | | | | New Orleans 46, Miami 34 | | | | Chicago 10, Cincinnati 45 | | | | Arizona 24, N.Y. Giants 17 | | | | Monday, Oct. 26 |
| Game | Time | TV | | Philadelphia 27, Washington 17 | | | | Open date: Baltimore,Denver,Detroit,Jacksonville,Seattle,Tennessee |
| WEEK 8 | | Sunday, Nov. 01 |
| Game | Time | TV | | Denver 7, Baltimore 30 | | | | Houston 31, Buffalo 10 | | | | Cleveland 6, Chicago 30 | | | | St. Louis 17, Detroit 10 | | | | Miami 30, N.Y. Jets 25 | | | | San Francisco 14, Indianapolis 18 | | | | N.Y. Giants 17, Philadelphia 40 | | | | Seattle 17, Dallas 38 | | | | Jacksonville 13, Tennessee 30 | | | | Oakland 16, San Diego 24 | | | | Carolina 34, Arizona 21 | | | | Minnesota 38, Green Bay 26 | | | | Monday, Nov. 02 |
| Game | Time | TV | | Atlanta 27, New Orleans 35 | | | | Open date: Cincinnati,Kansas City,Pittsburgh,Tampa Bay,Washington,New England |
| WEEK 9 | | Sunday, Nov. 08 |
| Game | Time | TV | | Green Bay 28, Tampa Bay 38 | | | | Arizona 41, Chicago 21 | | | | Kansas City 21, Jacksonville 24 | | | | Miami 17, New England 27 | | | | Washington 17, Atlanta 31 | | | | Baltimore 7, Cincinnati 17 | | | | Houston 17, Indianapolis 20 | | | | Carolina 20, New Orleans 30 | | | | Detroit 20, Seattle 32 | | | | San Diego 21, N.Y. Giants 20 | | | | Tennessee 34, San Francisco 27 | | | | Dallas 20, Philadelphia 16 | | | | Monday, Nov. 09 |
| Game | Time | TV | | Pittsburgh 28, Denver 10 | | | | Open date: Buffalo,Minnesota,N.Y. Jets,Oakland,St. Louis,Cleveland |
| WEEK 10 | | Thursday, Nov. 12 |
| Game | Time | TV | | Chicago 6, San Francisco 10 | | | | Sunday, Nov. 15 |
| Game | Time | TV | | Cincinnati 18, Pittsburgh 12 | | | | Atlanta 19, Carolina 28 | | | | Tampa Bay 23, Miami 25 | | | | New Orleans 28, St. Louis 23 | | | | Jacksonville 24, N.Y. Jets 22 | | | | Buffalo 17, Tennessee 41 | | | | Denver 17, Washington 27 | | | | Detroit 10, Minnesota 27 | | | | Kansas City 16, Oakland 10 | | | | Dallas 7, Green Bay 17 | | | | Philadelphia 23, San Diego 31 | | | | Seattle 20, Arizona 31 | | | | New England 34, Indianapolis 35 | | | | Monday, Nov. 16 |
| Game | Time | TV | | Baltimore 16, Cleveland 0 | | | | Open date: N.Y. Giants,Houston |
| WEEK 11 | | Thursday, Nov. 19 |
| Game | Time | TV | | Miami 24, Carolina 17 | | | | Sunday, Nov. 22 |
| Game | Time | TV | | Indianapolis 17, Baltimore 15 | | | | Seattle 9, Minnesota 35 | | | | New Orleans 38, Tampa Bay 7 | | | | Atlanta 31, N.Y. Giants 34 | | | | Washington 6, Dallas 7 | | | | Pittsburgh 24, Kansas City 27 | | | | Buffalo 15, Jacksonville 18 | | | | Cleveland 37, Detroit 38 | | | | San Francisco 24, Green Bay 30 | | | | Arizona 21, St. Louis 13 | | | | Cincinnati 17, Oakland 20 | | | | San Diego 32, Denver 3 | | | | N.Y. Jets 14, New England 31 | | | | Philadelphia 24, Chicago 20 | | | | Monday, Nov. 23 |
| Game | Time | TV | | Tennessee 20, Houston 17 | | |
| WEEK 12 | | Thursday, Nov. 26 |
| Game | Time | TV | | Green Bay 34, Detroit 12 | | | | Oakland 7, Dallas 24 | | | | N.Y. Giants 6, Denver 26 | | | | Sunday, Nov. 29 |
| Game | Time | TV | | Seattle 27, St. Louis 17 | | | | Carolina 6, N.Y. Jets 17 | | | | Tampa Bay 17, Atlanta 20 | | | | Miami 14, Buffalo 31 | | | | Washington 24, Philadelphia 27 | | | | Cleveland 7, Cincinnati 16 | | | | Indianapolis 35, Houston 27 | | | | Jacksonville 3, San Francisco 20 | | | | Kansas City 14, San Diego 43 | | | | Chicago 10, Minnesota 36 | | | | Arizona 17, Tennessee 20 | | | | Pittsburgh 17, Baltimore 20 | | | | Monday, Nov. 30 |
| Game | Time | TV | | New England at New Orleans | | ESPN |
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