| Last updated: Fri, May 25, 2012, 17:05 EDT |
| Date | Player | Pos. | Transaction |
| 5/21 | Jason Shirley | DT | cut |
| 5/16 | Tarren Lloyd | TE | cut |
| 5/16 | Joe Jon Finley | TE | signed |
| 5/15 | Armond Smith | RB | acquired from waivers |
| 5/11 | Phillip Dillard | LB | cut |
| 5/11 | D.J. Campbell | S | signed/draft choice, Four-year contract (through 2015) |
| 5/11 | Brad Nortman | P | signed/draft choice, Four-year contract (through 2015) |
| 5/11 | Josh Norman | CB | signed/draft choice, Four-year contract (through 2015) |
| 5/11 | Joe Adams | WR | signed/draft choice, Four-year contract (through 2015) |
| 5/11 | Frank Alexander | DE | signed/draft choice, Four-year contract (through 2015) |
| 5/11 | Amini Silatolu | G | signed/draft choice, Four-year contract (through 2015) |
| 5/11 | Luke Kuechly | LB | signed/draft choice, Four-year contract (fifth-year option) |
| 5/8 | Nick Harris | P | signed |
| 4/30 | Tarren Lloyd | TE | signed |
| 4/30 | Brenton Bersin | WR | signed |
| 4/30 | Will Blackwell | G | signed |
| 4/30 | Nate Chandler | DT | signed |
| 4/30 | Princeton McCarty | RB | signed |
| 4/30 | Wes Kemp | WR | signed |
| 4/30 | Ryan Van Bergen | DE | signed |
| 4/30 | Lyndon Rowells | RB | signed |
| 4/30 | Matt Reynolds | T | signed |
| 4/30 | Tauren Poole | RB | signed |
| 4/30 | Rico Wallace | WR | signed |
| 4/30 | Jared Green | WR | signed |
| 4/12 | Jordan Senn | LB | re-signed/unrestricted free agent |
| 4/10 | Steve Smith | WR | re-signed, Three-year extension (through 2014) |
| 4/4 | Reggie Smith | S | signed/unrestricted free agent |
| 3/30 | Bruce Campbell | T | traded, for RB Mike Goodson |
| 3/30 | Antwan Applewhite | DE | re-signed/unrestricted free agent |
| 3/23 | Chris Manno | WR | signed |
| 3/22 | Kenny Onatolu | LB | signed/unrestricted free agent, Three-year contract (through 2014) |
| 3/22 | Mike Pollak | G | signed/unrestricted free agent |
| 3/19 | Mike Tolbert | RB | signed/unrestricted free agent, Four-year contract (through 2015) |
| 3/16 | Haruki Nakamura | S | signed/unrestricted free agent, Three-year contract (through 2014) |
| 3/16 | Kenny Onatolu | LB | signed/unrestricted free agent, Three-year contract (through 2014) |
| 3/16 | DeMario Pressley | DT | cut |
| 3/15 | Derek Anderson | QB | re-signed/unrestricted free agent, One-year contract (through 2012) |
| 3/14 | Jason Baker | P | cut |
| 3/13 | Jeremy Shockey | TE | declared free agent |
| 3/13 | Geoff Schwartz | T | declared free agent |
| 3/13 | Thomas Williams | LB | declared free agent |
| 3/13 | Jordan Senn | LB | declared free agent |
| 3/13 | Legedu Naanee | WR | declared free agent |
| 3/13 | Cletis Gordon | CB | declared free agent |
| 3/13 | Omar Gaither | LB | declared free agent |
| 3/13 | Dan Connor | LB | declared free agent |
| 3/13 | Mackenzy Bernadeau | G | declared free agent |
| 3/13 | Antwan Applewhite | DE | declared free agent |
| 3/13 | Derek Anderson | QB | declared free agent |
| 3/13 | Travelle Wharton | G | cut |
| 3/13 | Geoff Hangartner | C | re-signed, Three-year extension (through 2014) |
| 3/10 | Richie Brockel | TE | re-signed/exclusive rights free agent |
| 3/10 | R.J. Stanford | CB | re-signed/exclusive rights free agent |
| 3/9 | Dwayne Jarrett | WR | suspended, 3 games (NFL Personal Conduct Policy) |
| 3/7 | Adi Kunalic | K | cut |
| 3/6 | Justin Medlock | K | signed |
| 1/6 | Reggie Sullivan | CB | signed |
| 1/6 | Phillip Dillard | LB | signed |
| 1/6 | Roger Allen | G | signed |
| 1/6 | Greg Smith | TE | signed |
| 12/30 | DeMario Pressley | DT | Activated from the Practice Squad |
| 12/30 | Legedu Naanee | WR | Placed on IR, foot |
| 12/28 | Reggie Sullivan | CB | practice squad addition |
| 12/23 | Jonathan Nelson | S | Activated from the Practice Squad |
| 12/23 | Captain Munnerlyn | CB | Placed on IR, hamstring |
| 12/20 | Chip Vaughn | S | practice squad addition |
| 12/17 | Jeff Byers | C | Activated from the Practice Squad |
| 12/17 | Bryant Browning | G | Placed on IR, wrist |
| 12/13 | Adi Kunalic | K | signed, Three-year contract |
| 12/13 | Jason Phillips | LB | Placed on IR, right calf |
| 12/7 | Ogemdi Nwagbuo | DT | signed |
| 12/7 | DeMario Pressley | DT | practice squad addition |
| 12/6 | Sione Fua | DT | Placed on IR, right hamstring |
| 12/6 | Terrell McClain | DT | Placed on IR, left knee |
| 12/6 | Jason Shirley | DT | Activated from the physically unable to perform list |
| 12/2 | Bryant Browning | G | Activated from the Practice Squad |
| 12/2 | Roger Allen | G | practice squad addition |
| 11/30 | Reggie Wells | G | cut |
| 11/30 | Kory Sheets | RB | practice squad addition |
| 11/30 | Garrett Chisolm | G | practice squad addition |
| More Transactions |
