| Last updated: Fri, May 18, 2012, 17:21 EDT |
| Date | Player | Pos. | Transaction |
| 5/14 | Case Keenum | QB | signed |
| 5/14 | Rennie Moore | DE | signed |
| 5/14 | Nate Menkin | T | signed |
| 5/14 | Davin Meggett | RB | signed |
| 5/14 | Desmond Marrow | CB | signed |
| 5/14 | Mario Louis | WR | signed |
| 5/14 | Shawn Loiseau | LB | signed |
| 5/14 | Delano Johnson | LB | signed |
| 5/14 | Phillip Supernaw | TE | signed |
| 5/14 | Cody White | G | signed |
| 5/14 | Greg Williams | LB | signed |
| 5/14 | Ben Jones | C | signed/draft choice, Four-year contract (through 2015) |
| 5/14 | Keshawn Martin | WR | signed/draft choice, Four-year contract (through 2015) |
| 5/14 | Jared Crick | DE | signed/draft choice, Four-year contract (through 2015) |
| 5/14 | Randy Bullock | K | signed/draft choice, Four-year contract (through 2015) |
| 5/14 | Nick Mondek | T | signed/draft choice, Four-year contract (through 2015) |
| 5/14 | Tracy Robertson | DE | signed |
| 5/14 | Dwight Jones | WR | signed |
| 5/14 | Eddie Pleasant | S | signed |
| 5/14 | Loni Fangupo | NT | signed |
| 5/14 | Logan Brock | TE | signed |
| 5/14 | Derrell Bryant | LB | signed |
| 5/14 | Jason Ford | RB | signed |
| 5/14 | Jonathan Grimes | RB | signed |
| 5/14 | David Hunter | NT | signed |
| 5/14 | Jerrell Jackson | WR | signed |
| 5/11 | John Beck | QB | signed |
| 5/7 | Shayne Graham | K | signed |
| 5/1 | Jacoby Jones | WR | cut |
| 4/13 | Tim Dobbins | LB | re-signed/unrestricted free agent |
| 4/12 | Bradie James | LB | signed/unrestricted free agent |
| 4/5 | Quintin Demps | S | re-signed/unrestricted free agent |
| 3/30 | Donnie Jones | P | signed/unrestricted free agent, Two-year contract (through 2013) |
| 3/17 | Chris Myers | C | re-signed/unrestricted free agent, Four-year contract (through 2015) |
| 3/13 | Lawrence Vickers | RB | cut |
| 3/13 | Jason Allen | CB | declared free agent |
| 3/13 | Dominique Barber | S | declared free agent |
| 3/13 | Mike Brisiel | G | declared free agent |
| 3/13 | Tim Bulman | DE | declared free agent |
| 3/13 | Jake Delhomme | QB | declared free agent |
| 3/13 | Tim Dobbins | LB | declared free agent |
| 3/13 | Joel Dreessen | TE | declared free agent |
| 3/13 | Jeff Garcia | QB | declared free agent |
| 3/13 | Bryant Johnson | WR | declared free agent |
| 3/13 | Chris Myers | C | declared free agent |
| 3/13 | Neil Rackers | K | declared free agent |
| 3/13 | Kasey Studdard | G | declared free agent |
| 3/13 | Matt Turk | P | declared free agent |
| 3/13 | Derrick Ward | RB | declared free agent |
| 3/13 | Mario Williams | DE | declared free agent |
| 3/13 | Quintin Demps | S | declared free agent |
| 3/12 | Eric Winston | T | cut |
| 3/12 | Matt Leinart | QB | cut |
| 3/9 | Brett Hartmann | P | suspended, 4 games (NFL Substance Abuse Policy) |
| 3/5 | Jon Weeks | C | re-signed, Four-year extension (through 2015) |
| 3/5 | Arian Foster | RB | re-signed, Five-year extension (through 2016) |
| 1/18 | Trindon Holliday | WR | signed |
| 1/18 | Juaquin Iglesias | WR | signed |
| 1/18 | Torri Williams | S | signed |
| 1/18 | Cody Wallace | C | signed |
| 1/18 | Ra'Shon Harris | DE | signed |
| 1/18 | Derrell Smith | LB | signed |
| 1/18 | Javarris Williams | RB | signed |
| 1/9 | Derrick Mason | WR | retired |
| 12/13 | Juaquin Iglesias | WR | practice squad addition |
| 12/13 | Jeff Maehl | WR | Activated from the Practice Squad |
| 12/12 | Derrick Mason | WR | cut |
| 12/6 | Matt Turk | P | signed |
| 12/6 | Kellen Clemens | QB | cut |
| 12/6 | Brett Hartmann | P | Placed on IR, torn left ACL |
| 12/6 | Jeff Garcia | QB | signed |
| 11/29 | Jake Delhomme | QB | signed |
| 11/29 | Matt Leinart | QB | Placed on IR, fractured left collarbone |
| 11/23 | Kellen Clemens | QB | signed |
| 11/23 | Thaddeus Gibson | LB | practice squad deletion |
| 11/23 | Matt Schaub | QB | Placed on IR, foot |
| 11/23 | Ra'Shon Harris | DE | practice squad addition |
| More Transactions |
