| Last updated: Tue, May 21, 2013, 02:03 EDT |
| Date | Player | Pos. | Transaction |
| 5/17 | Toben Opurum | RB | signed |
| 5/17 | Lucas Patterson | G | Placed on IR, undisclosed |
| 5/15 | Braden Wilson | RB | signed/draft choice, Four-year contract (through 2016) |
| 5/14 | De'Quan Menzie | CB | cut |
| 5/14 | Buddy Jackson | CB | acquired from waivers |
| 5/14 | Matt Reynolds | T | acquired from waivers |
| 5/13 | Ryan D'Imperio | RB | cut |
| 5/13 | Knile Davis | RB | signed/draft choice, Four-year contract (through 2016) |
| 5/13 | Nate Eachus | RB | cut |
| 5/13 | Jose Gumbs | S | cut |
| 5/13 | Risean Broussard | DT | signed |
| 5/13 | Greg Castillo | CB | signed |
| 5/13 | Justin Glenn | S | signed |
| 5/13 | James Rogers | CB | signed |
| 5/13 | Miguel Chavis | DE | signed |
| 5/13 | Jordan Roberts | RB | signed |
| 5/10 | Mike Catapano | LB | signed/draft choice, Four-year contract (through 2016) |
| 5/10 | Eric Kush | C | signed/draft choice, Four-year contract (through 2016) |
| 5/2 | Cory Greenwood | LB | cut |
| 5/2 | Patrick DiMarco | RB | cut |
| 5/2 | Alex Tanney | QB | cut |
| 5/2 | Bryan Mattison | C | cut |
| 5/1 | Ridge Wilson | LB | signed |
| 5/1 | Rico Richardson | WR | signed |
| 5/1 | Bradley McDougald | S | signed |
| 5/1 | Josh Martin | LB | signed |
| 5/1 | Brad Madison | DE | signed |
| 5/1 | Rob Lohr | DE | signed |
| 5/1 | Anthony Sherman | RB | traded, for CB Javier Arenas |
| 5/1 | A.J. Hawkins | G | signed |
| 5/1 | Demetrius Harris | TE | signed |
| 5/1 | Frankie Hammond | WR | signed |
| 5/1 | Otha Foster | S | signed |
| 5/1 | Darin Drakeford | LB | signed |
| 5/1 | Tyler Bray | QB | signed |
| 5/1 | Colin Kelly | T | signed |
| 4/18 | Orie Lemon | LB | signed/unrestricted free agent |
| 4/15 | Akeem Jordan | LB | signed/unrestricted free agent |
| 4/12 | Zac Diles | LB | signed/unrestricted free agent, One-year contract (through 2013) |
| 4/4 | Frank Zombo | LB | signed/unrestricted free agent |
| 4/3 | Tommie Draheim | C | signed/unrestricted free agent, One-year contract (through 2013) |
| 4/2 | Rich Ranglin | G | cut |
| 4/1 | Edgar Jones | LB | re-signed/unrestricted free agent |
| 4/1 | Andy Studebaker | LB | cut |
| 3/29 | Matt Szymanski | K | cut |
| 3/27 | Chad Kilgore | LB | signed/unrestricted free agent |
| 3/21 | Ryan D'Imperio | RB | signed |
| 3/21 | Branden Albert | T | re-signed/franchise, One-year tender (through 2013) |
| 3/20 | Thomas Gafford | C | re-signed/unrestricted free agent, One-year contract (through 2013) |
| 3/15 | Sean Smith | CB | signed/unrestricted free agent, Three-year contract (through 2015) |
| 3/15 | Geoff Schwartz | G | signed/unrestricted free agent |
| 3/14 | Matt Cassel | QB | cut |
| 3/13 | Donnie Avery | WR | signed/unrestricted free agent, Three-year contract (through 2015) |
| 3/13 | Bryan Mattison | C | re-signed/unrestricted free agent |
| 3/13 | Chase Daniel | QB | signed/unrestricted free agent, Three-year contract (through 2015) |
| 3/13 | Mike DeVito | DE | signed/unrestricted free agent, Three-year contract (through 2015) |
| 3/13 | Anthony Fasano | TE | signed/unrestricted free agent, Four-year contract (through 2016) |
| 3/13 | Dunta Robinson | CB | signed, Three-year contract (through 2015) |
| 3/12 | Brady Quinn | QB | declared free agent |
| 3/12 | Peyton Hillis | RB | declared free agent |
| 3/12 | Shaun Smith | DE | declared free agent |
| 3/12 | Leon Williams | LB | declared free agent |
| 3/12 | Thomas Gafford | C | declared free agent |
| 3/12 | Brandon Siler | LB | declared free agent |
| 3/12 | Russ Hochstein | G | declared free agent |
| 3/12 | Edgar Jones | LB | declared free agent |
| 3/12 | Ryan Lilja | G | declared free agent |
| 3/12 | Alex Smith | QB | traded, for 2nd-round pick in 2013, 2014 pick |
| 3/12 | Abram Elam | S | declared free agent |
| 3/12 | Glenn Dorsey | DE | declared free agent |
| 3/12 | Travis Daniels | S | declared free agent |
| 3/12 | Martin Rucker | TE | declared free agent |
| 3/12 | Kyle McCarthy | S | declared free agent |
| 3/12 | Bryan Mattison | C | declared free agent |
| 3/12 | Steve Maneri | TE | declared free agent |
| 3/12 | Ropati Pitoitua | DE | declared free agent |
| 3/12 | Jake O'Connell | TE | declared free agent |
| 3/7 | Eric Winston | T | cut |
| 3/4 | Dwayne Bowe | WR | re-signed, Five-year extension (through 2017) |
| 3/4 | Branden Albert | T | Designated franchise player |
| 3/4 | Dustin Colquitt | P | re-signed, Five-year extension (through 2017) |
| 2/19 | Steve Breaston | WR | cut |
| 2/19 | Kevin Boss | TE | cut |
| 2/18 | Husain Abdullah | S | signed |
| 2/11 | Kevin Brock | TE | signed |
| 2/11 | Mardy Gilyard | WR | signed |
| 2/11 | Marcus Dixon | DT | signed |
| 2/4 | Jake O'Connell | TE | Taken off IR, ankle |
| 2/4 | Allen Bailey | DE | Taken off IR, ankle |
| 2/4 | Dwayne Bowe | WR | Taken off IR, ribs |
| 2/4 | Terrance Copper | WR | Taken off IR, knee |
| 2/4 | Martin Rucker | TE | Taken off IR, torn right ACL |
| 2/4 | Kyle McCarthy | S | Taken off IR, knee |
| 2/4 | De'Quan Menzie | CB | Taken off IR, undisclosed |
| 2/4 | Alex Tanney | QB | Taken off IR, undisclosed |
| 2/4 | Rodney Hudson | C | Taken off IR, broken right leg |
| 2/4 | Kevin Boss | TE | Taken off IR, concussion |
| 2/4 | Glenn Dorsey | DE | Taken off IR, calf |
| 1/26 | Ryan Durand | G | signed |
| 1/25 | Tyler Shoemaker | WR | signed |
| 1/18 | Daniel Muir | DT | signed |
| 1/17 | Steven Baker | T | signed |
| 12/29 | Junior Hemingway | WR | Activated from the Practice Squad |
| 12/29 | Terrance Copper | WR | Placed on IR, knee |
| 12/19 | Matt Szymanski | K | practice squad addition |
| 12/15 | Rich Ranglin | G | Activated from the Practice Squad |
| 12/15 | Dwayne Bowe | WR | Placed on IR, ribs |
| 12/12 | Dustin Waldron | T | practice squad addition |
| 12/8 | Hayworth Hicks | G | cut |
| 12/8 | Josh Bellamy | WR | Activated from the Practice Squad |
| 12/6 | Allen Bailey | DE | Placed on IR, ankle |
| 12/6 | Leon Williams | LB | signed |
| 12/5 | Jose Gumbs | S | practice squad addition |
| 12/2 | Patrick DiMarco | RB | Activated from the Practice Squad |
| 12/1 | Jovan Belcher | LB | deceased |
| 12/1 | Patrick DiMarco | RB | Activated from the Practice Squad |
| 11/29 | Quan Sturdivant | LB | practice squad addition |
| 11/29 | Matt Szymanski | K | practice squad deletion |
| 11/28 | Hayworth Hicks | G | acquired from waivers |
| 11/27 | Rich Ranglin | G | practice squad addition |
| 11/27 | Bryan Kehl | LB | cut |
| 11/24 | Rich Ranglin | G | cut |
| 11/24 | Jamar Newsome | WR | Activated from the Practice Squad |
| More Transactions |
