| Last updated: Tue, May 22, 2012, 18:28 EDT |
| Date | Player | Pos. | Transaction |
| 5/18 | Keenan Robinson | LB | signed/draft choice, Four-year contract (through 2015) |
| 5/14 | Tim Hightower | RB | re-signed/unrestricted free agent, One-year contract (through 2012) |
| 5/6 | Kelvin Bolden | WR | cut |
| 5/6 | Alfred Morris | RB | signed/draft choice, Four-year contract (through 2015) |
| 5/6 | Tom Compton | T | signed/draft choice, Four-year contract (through 2015) |
| 5/6 | Brian Hernandez | WR | signed |
| 5/6 | Delvin Johnson | DT | signed |
| 5/6 | Sam Kirkland | WR | signed |
| 5/6 | Nick Martinez | G | signed |
| 5/6 | Beau Reliford | TE | signed |
| 5/6 | Vaughn Meatoga | DT | cut |
| 5/5 | Adam Gettis | G | signed/draft choice, Four-year contract (through 2015) |
| 5/4 | Jordan Bernstine | CB | signed/draft choice, Four-year contract (through 2015) |
| 5/4 | Richard Crawford | CB | signed/draft choice, Four-year contract (through 2015) |
| 5/4 | Michael Shaw | RB | cut |
| 5/3 | Chase Minnifield | CB | signed |
| 5/3 | Vaughn Meatoga | NT | signed |
| 5/3 | Kelvin Bolden | WR | signed |
| 5/3 | Lennon Creer | RB | signed |
| 5/3 | Grant Garner | C | signed |
| 5/3 | Michael Shaw | RB | signed |
| 5/3 | Antwon Bailey | RB | signed |
| 5/3 | Brian McNally | LB | signed |
| 5/3 | Lance Lewis | WR | signed |
| 5/3 | Monte Lewis | LB | signed |
| 5/3 | Donnell Holt | LB | signed |
| 5/3 | Darius Hanks | WR | signed |
| 5/1 | Jabar Gaffney | WR | cut |
| 4/30 | Neil Rackers | K | signed/unrestricted free agent, One-year contract (through 2012) |
| 4/30 | Jonathan Goff | LB | signed/unrestricted free agent |
| 4/28 | John Beck | QB | cut |
| 4/24 | Chris Wilson | LB | signed |
| 4/24 | Neil Rackers | K | signed/unrestricted free agent, One-year contract (through 2012) |
| 4/23 | Bryan Kehl | LB | signed/unrestricted free agent |
| 4/13 | Tanard Jackson | S | signed, One-year contract (through 2012) |
| 4/13 | London Fletcher | LB | re-signed/unrestricted free agent, Two-year contract (through 2013) |
| 4/10 | Leigh Torrence | CB | signed/unrestricted free agent |
| 4/10 | Madieu Williams | S | signed/unrestricted free agent |
| 4/10 | Kedric Golston | DT | re-signed/unrestricted free agent |
| 4/9 | James Lee | T | signed/unrestricted free agent |
| 3/21 | Rex Grossman | QB | re-signed/unrestricted free agent, One-year contract (through 2012) |
| 3/20 | Adam Carriker | DE | re-signed/unrestricted free agent, Four-year contract (through 2015) |
| 3/16 | Cedric Griffin | CB | signed/unrestricted free agent, One-year contract (through 2012) |
| 3/15 | Brandon Meriweather | S | signed/unrestricted free agent, Two-year contract (through 2013) |
| 3/13 | Kory Lichtensteiger | G | Restricted Free Agent |
| 3/13 | David Anderson | WR | declared free agent |
| 3/13 | Phillip Buchanon | CB | declared free agent |
| 3/13 | London Fletcher | LB | declared free agent |
| 3/13 | Keyaron Fox | LB | declared free agent |
| 3/13 | Kedric Golston | DT | declared free agent |
| 3/13 | Rex Grossman | QB | declared free agent |
| 3/13 | Tim Hightower | RB | declared free agent |
| 3/13 | LaRon Landry | S | declared free agent |
| 3/13 | Sean Locklear | T | declared free agent |
| 3/13 | Rocky McIntosh | LB | declared free agent |
| 3/13 | Donte' Stallworth | WR | declared free agent |
| 3/13 | Byron Westbrook | CB | declared free agent |
| 3/13 | Adam Carriker | DE | re-signed/unrestricted free agent, Four-year contract (through 2015) |
| 3/13 | Adam Carriker | DE | declared free agent |
| 3/13 | Pierre Garcon | WR | signed/unrestricted free agent, Five-year contract (through 2016) |
| 3/13 | Josh Morgan | WR | signed/unrestricted free agent, Five-year contract (through 2016) |
| 3/12 | Mike Sellers | RB | cut |
| 3/12 | Oshiomogho Atogwe | S | cut |
| 1/4 | Trent Williams | T | suspension lifted |
| 1/4 | Fred Davis | TE | suspension lifted |
| 1/3 | Nevin McCaskill | T | signed |
| 1/3 | Tristan Davis | RB | signed |
| 1/3 | Jonathan Crompton | QB | signed |
| 1/3 | Travon Bellamy | S | signed |
| 12/28 | Stafon Johnson | RB | practice squad addition |
| 12/27 | Aldrick Robinson | WR | Activated from the Practice Squad |
| 12/27 | Ryan Torain | RB | cut |
| 12/20 | Michael Hamlin | S | practice squad addition |
| 12/20 | Rob Myers | TE | Activated from the Practice Squad |
| 12/20 | Dominique Byrd | TE | cut |
| 12/20 | Doug Worthington | DE | Activated from the Practice Squad |
| 12/20 | Schuylar Oordt | TE | practice squad addition |
| 12/15 | LaRon Landry | S | Placed on IR, Achilles |
| 12/13 | Chris Baker | DT | Placed on IR, quadriceps |
| 12/13 | Richard Quinn | TE | signed |
| 12/7 | Dominique Byrd | TE | signed |
| 12/6 | Cole Pemberton | T | practice squad addition |
| 12/6 | Trent Williams | T | suspended, 4 games (NFL Substance Abuse Policy) |
| 12/6 | Fred Davis | TE | suspended, 4 games (NFL Substance Abuse Policy) |
| 12/6 | Chris Baker | DT | Activated from the Practice Squad |
| 11/29 | Travon Bellamy | S | practice squad addition |
| 11/29 | Brandyn Thompson | CB | Activated from the Practice Squad |
| 11/29 | D.J. Johnson | CB | cut |
| More Transactions |
