Sizemore had been demoted to Triple-A last month after hitting .242 with two home runs and 13 RBI in 149 at-bats. He will play in left field during Saturday's game at Boston.
A-Rod doubled, drove in a run and scored four runs in the game.
Rodriguez last scored four times in a game on July 2, 2008.
Rodriguez hit in his seventh straight game. He's hitting .407 over the streak.
LaRoche doubled and drove in a run and recorded his first multi-hit game since July 8.
It was his first four-hit game since September 4, 2012.
LaRoche also took the mound to pitch a perfect ninth inning, striking out one. It was his first pitching appearance in the Majors and first overall since Double-A Greenville in 2003.
Singleton, who made his MLB debut in 2014, began this season at Triple and was recalled at the end of June. In 16 games since the call-up, the young slugger hit .205 with just one home run and 16 strikeouts.
Ortiz was 3-for-3 with a walk and two RBIs to pace Boston's offensive attack. He drove in a run with a first-inning double and added another on a fifth-inning single, both of which came off Sale. The veteran DH now has 58 RBIs on the season.
Ortiz entered the game hitting just .162 with 12 RBIs off left-handed pitchers this season.
Gattis is not sitting for struggling. He has hit safely in six of his last seven games and has 16 home runs and 58 RBI on the year despite a slow start.
Murphy was scratched from the lineup, leading to speculation that a deal was in the works. CBSSports.com's baseball insider Jon Heyman reports that the Indians will receive Eric Stamets from the Angels.
Murphy is hitting .296 with .781 OPS for the Indians this year. He's started games in left field, right field and DH.
Stamets, a shortstop, was hitting .248 at Double-A Arkansas.
The reason for his being scratched wasn't made apparent. It's possible he's the subject of trade negotiations. A report from the Los Angeles Times said that the Angels were close to finalizing a deal to acquire Murphy.