Encarnacion got the party started when he blasted a three-run shot in the first inning. He added a two-run bomb in the sixth inning before launching a grand slam in the seventh.
With the trio of homers, Encarnacion pushed his hitting streak up to 24 games, which is the longest streak in the Major Leagues this season--it's also the fifth-longest in team history, according to ESPN.com.
Sano will be the designated hitter and bat fourth on Saturday.
Ortiz is unlikely to play on Saturday, and his status for the series-finale on Sunday is still in question.
Sano is on a four-game hitting streak with two home runs and six RBI.
Encarnacion's double was the only source of runs for the Jays, but it was enough to add to his impressive hitting stretch. He has seven multi-hit games over the 22-game streak, and his season average has gone from .234 to .264.
LaRoche has hit safely in five of his last six games, but has a mere 14 hits in 86 at-bats against southpaws this season.
Encarnacion's hit streak is now at 21 games, and his sixth-inning slam was the second of the season and the eighth of his career. Encarnacion now has 26 home runs on the season and seven homers and 23 RBIs in August.
Gattis got the scoring started with his first solo blast in the second inning. He then ended the scoring with another solo shot in the eighth, giving him 22 big flies on the year.
Gattis is on fire right now, as he is batting .351 with five home runs and nine RBI over his last 10 games.
He has six home runs over the 20-game stretch, and his overall batting average is up to .265 which is the highest it's been since the very start of the season.
Encarnacion led a 17-hit attack with a sacrifice fly in the first to put Toronto on the board and flexed his muscle in the fourth with a solo homer, his 24th of the season.
With four RBIs on the day Encarnacion now has 74 on the season, and also extended his hitting streak to 19 games.