Trumbo blasted a solo shot in the second inning to tie the game a 1-1. He then added a two-run shot in the ninth inning. Those were the only runs the Mariners would muster up however.
The pair of big flies give Trumbo a total of 19 on the season. It was just his second multi-homer game of the season, and his first since May 12 when he was with the Diamondbacks.
Ortiz's home run gave the Red Sox a 3-2 lead over the Yankees, and they would go on to win 4-3. Ortiz has now homered in back-to-back games and in three of his last four.
Rodriguez is hitting .255 with 26 home runs and 69 RBI in 420 at-bats this season.
Encarnacion got the party started when he blasted a three-run shot in the first inning. He added a two-run bomb in the sixth inning before launching a grand slam in the seventh.
With the trio of homers, Encarnacion pushed his hitting streak up to 24 games, which is the longest streak in the Major Leagues this season--it's also the fifth-longest in team history, according to ESPN.com.
Sano will be the designated hitter and bat fourth on Saturday.
Ortiz is unlikely to play on Saturday, and his status for the series-finale on Sunday is still in question.
Sano is on a four-game hitting streak with two home runs and six RBI.
Encarnacion's double was the only source of runs for the Jays, but it was enough to add to his impressive hitting stretch. He has seven multi-hit games over the 22-game streak, and his season average has gone from .234 to .264.
LaRoche has hit safely in five of his last six games, but has a mere 14 hits in 86 at-bats against southpaws this season.