Holliday has five hits in his last two games.
Byrd had struggled early on in the season, hitting just .163 during the first month.
"It's the toughest time since I turned things back around two years ago," Byrd said. "I've been putting in a lot of time in with [hitting coach] Don Long and things are slowly starting to come around."
Tuesday marked the first time this season that Byrd notched two extra-base hits in one game.
"The home run was exciting and the double in the ninth inning was especially exciting because it's a lot easier to manage a game with a six-run lead than a one-run lead or being down a run," Reds manager Bryan Price said about Byrd.
Johnson hit a three-run home run in the fourth inning, then reached the milestone with a single in the sixth.
Johnson had a bases-loaded walk in the seventh for a fourth RBI on the night. He has six home runs and 17 RBI this year and lifted his average to .266.
Marte's homer was a second-inning solo shot of Reds starter Michael Lorenzen.
The seven homers for Marte is currently the most for the Pirates.
The team announced that Pagan had a laceration on his left middle finger. This is just the second start Pagan has missed this season and snaps a streak of 19 starts in a row in center. He was replaced in the lineup by Gregor Blanco.
Pagan said he got his left middle fingernail "cracked pretty good" when spiked in Monday's game. He was able to pick up two singles early in the game before finishing the night 2 for 4 at the plate.
Pagan has hit .350/.373/.447 with eight RBI and three stolen bases in 103 at-bats.
Pence has yet to play this season after suffering a broken forearm during spring training. A decision on the next step in his rehab will be made in the coming days.
"Like I was saying in the spring, it’s the stuff that Seitz preaches," Johnson said. "Staying on top of it, trying to be a consistent as you can, not deviate — good or bad, just keep working."
Johnson said he's benefited "big time" by following Seitzer's tenets as well as his attention to detail and persistence.
"He’s so big on not trying to do too much, stay in the middle – all the stuff he says, just BP and the approach and having all that kind of take care of some stuff and clean stuff up," Johnson said. "For me personally, I think sometimes you turn up the knob a little bit and try to do too much, or maybe you get going and you feel pretty good and you keep trying to do better and better, and hit the ball farther and farther, or whatever, instead of just continuing to do the same thing and let the results take care of themselves."
Johnson comes into Tuesday's game hitting .246/.292/.525 with five home runs and 13 RBI in 61 at-bats.
It's just the second time Myers has gotten a break from starting this season. Will Venable is starting in center field as he did the last time Myers sat, but rather than leading off, Venable is batting sixth Tuesday. Second baseman Cory Spangenberg is leading off for the Padres Tuesday.
The Padres are road favorites (-120) in San Francisco Tuesday.