"That's something we have to deal with through the Commissioner's office if we felt it [an extension] is needed," Weiss said. "I'm still not sure on that yet."
Axford is on the family medical emergency leave after his son was bit by a rattle snake during spring training.
"That was a relief to me and to the organization," Cubs President Theo Epstein said. "So he is going to take it slow and get back to full strength, then come back."
Ramirez was placed on the 15-day disabled list in order to rest the shoulder.
Siegrist pitched a scoreless eighth inning before the Cardinals scored two runs in the bottom of the eighth inning. Siegrist remained in the game for the ninth inning and he was able to record the last three outs to earn his first save of the season.
In four appearances this season, Siegrist has yet to surrender a run over 2 1/3 innings.
Grilli came in during the ninth inning with a one run lead and got the first two outs, but he then walked Edwin Encarnacion. He was then able to get Dioner Navarro to ground out to end the game.
Grilli is now a perfect five for five on save opportunities this season with a 1.80 ERA.
After Antonio Bastardo allowed two hits and a run in the ninth inning, Melancon relieved him to record last the out of the game.
Familia struck out the first two batters of the ninth inning, before surrendering a hit, but he was able to earn the save without surrendering a run. Familia is a perfect five for five on save opportunities this season.
With the game in hand, Rivero entered the game in a no-pressure situation. He did allow three hits and an earned run, which was scored via a Ryan Howard RBI single. His fastball was clocking in the mid-90s, which helped him strike out Cody Asche and Darin Ruf.
Liberatore will be available for Friday's game against the Rockies. Prior to Opening Day, he was optioned to the minors. During spring training, Liberatore threw 10 1/3 innings and didn't allow one run.
He continued mowing them down Friday afternoon against the host Cubs. Kimbrel retired the first two batters before allowing a single to Dexter Fowler. With slugger Anthony Rizzo looming on deck, he enduced Jorge Soler to ground out to nail down his fourth save in his last four appearances.
Kimbrel has yet to surrender a run this year.
Black has been sidelined since mid-March in spring training with a shoulder injury. He has allowed one run on one hit and two walks while striking out two in two innings of relief in a minor-league rehab assignment with Class A St. Lucie.