Ziegler arrived in a tie game Sunday against Oakland and left with a 7-4 deficit. He gave up three runs on six hits in just one inning.
He loaded the bases in the 10th, but slithered out of the jam with a double play and groundout. He had no such fortune in the 11th, when three two-out singles and a hit-by-pitch resulted in his second loss of the season.
His ERA still sits at a fine 1.88.
With normal closer Trevor Rosenthal on paternity leave, Siegrist came in during a two-run game in the ninth inning and didn't allow a hit, striking out two batters. He allowed two hits and one run in 1/3 inning in Friday's loss.
Siegrist has been a jack-of-all-trades for the Cards this season, with a 5-1 record and 24 holds to go along with the six saves.
Papelbon gave up two hits and faced a first-and-third situation with Miami's Dee Gordon at the plate in a 7-4 game, but got Gordon to ground to short to finish the contest.
Papelbon now has five saves since being dealt to Washington in late July.
Hand couldn't make it out of the fifth, giving up eight hits and five runs in 4 2/3 innings to end a two-game losing streak and drop back to .500 at 4-4.
Hand labored through 80 pitches, striking out five and walking two, but was hit hard the second time through the lineup.
Familia allowed two hits in the ninth inning of a one-run game, but struck out two hitters as well to close out the game. His ERA is now down to 1.67 and his ranks fourth in the NL in saves.
Ramirez, who landed on the disabled list a month ago with abdominal soreness, has pitched in just 13 games this season and compiled a 3.12 ERA.
Rearick made his MLB debut and appeared in five games with the Padres this season, allowing four runs in three innings. He was 0-3 with a 5.23 ERA in 37 games with Triple-A El Paso.
Roberts was then optioned to the team's Triple-A affiliate. He has a 5.79 ERA over 9 1/3 innings this season.