Escobar did his only damage in the fourth inning when he ripped a 3-2 pitch off James Paxton over the left center field wall for a solo home run, his first of the season. Escobar, who also struck out twice, boosted his average to .171 in 35 at-bats this season.
Hardy, who rejoined the team Saturday, is still on the 15-day DL with the shoulder injury and has not yet played in a rehab game on his road to recovery.
Hardy, who is currently on the 15-day DL with a left shoulder strain, has yet to play in a rehab game and is still working with the team to determine his next step.
"I think he still feels just a little bit [on his swing]," bench coach John Russell, filling in for manager Buck Showalter, said on Saturday. "I can't go into a lot of detail. I'll let Buck handle more of that. I do know he's making very good progress, so knock on wood that's a good sign."
Eduardo Escobar will start his third game of the year at shortstop, batting eighth in the lineup.
Marwin Gonzalez gets his third start of the year at first base, batting eighth in the lineup.
The Astros are +105 money line underdogs at Oakland.
Hardy has not played this season due to a shoulder strain and he has been working out with the team's Triple-A affiliate in Norfolk.
Finnegan started the season at Double-A, while Calixte was 0 for 2 in his lone appearance this season.
Manager Ned Yost said Finnegan will work out of the bullpen initially and he does not have a definitive role for him yet, reports The Kansas City Star.
Holt has started games at second, third, short and center. With Friday's game, Holt will have three starts at shortstop, more than any other position. It's the second time in four games he's gotten the start at short ahead of Bogaerts.
Boston and Baltimore are even with -105 money lines for the game.