Blackmon will get a break after starting 12 straight games, and Brandon Barnes will man both center field and the leadoff spot in the lineup. Tulowitzki is sitting for the second time in three games and will be replaced by Daniel Descalso, who's batting eighth.
The Rockies are underdogs (+132) on Monday, per VegasInsider.com.
Brandon Barnes will fill in for Gonzalez and bat sixth.
Herrera is slashing .220/.238/.268 for the season.
The rest of the Cubs' lineup is the same from Saturday.
Guerrero will hit sixth after Justin Turner filled in his spot a day ago.
Norris had a day off on Saturday. Alexi Amarista is also back in the lineup and will play third base. This moves Cory Spangenberg from third to second base. Spangenberg will bat six Amarista will hit eighth.
Outfielder Will Venable, who hit fifth on Saturday, will bat second Sunday.
In addition, outfielder Jason Heyward is out due to left hip tightness.
Peralta will hit third, Reynolds will his hit seventh and Kozma will bat ninth.
Crawford rested on Thursday and appears to be doing the same for this game as well. In his place at shortstop will be Joaquin Arias, who is penciled in to bat eighth.
Alvarez is replaced by Sean Rodriguez, who gets his second start of the year at first base. Rodriguez will hit sixth.
Walker's absence requires shifts at all other infield positions. Josh Harrison moves over from third place to replace Walker at second. Jung Ho Kang moves to third from shortstop, and Jordy Mercer returns to the lineup at short, for just the second time in eight games.
Segura, who has a broken finger, has an MRI scheduled for Monday to determine whether his injury has healed or not. The expectation is that he'll be good to go. It hasn't been decided whether Segura will have a brief minor-league rehab assignment or not.
"I think we're down to days with them," said manager Craig Counsell. "I'm optimistic. They're taking big steps at this point, which is what you want to see. You kind of see the light here with both of those guys."
In 34 games, Segura is slashing .262/.306/.373.
He's replaced by Pedro Ciriaco, who starts for the second time this season at the hot corner.