Spangenberg will return with a slash line of .254/.304/.356 and 44 strikeouts in just 177 at-bats.
He went on the disabled list Friday with what was described as right elbow inflammation, but an MRI scheduled for Monday could reveal it to be worse.
"I'm prepared for (being told) it just needs some rest and if it's ... the worst (outcome)," Burnett told the Pittsburgh Tribune-Review. "It's a matter of doing enough treatment and building up some pain tolerance so I can stay on mound in the stretch run."
That might be difficult considering how poorly Burnett has performed since the All-Star break. He has surrendered 18 runs on 32 hits in 16 innings and has lost his last two decisions.
Tillman was scheduled to pitch Monday.
He hopes to perform as well Friday as he has in his last four outings, during which he has allowed just three earned runs in 29 2/3 innings to drop his ERA to 4.35, its lowest point since his second start of the year.
Panik missed time last week because of the back issue, but he is considered day to day. Panik will undergo tests Monday if the issue persists.
Chisenhall homered Saturday for the team's lone run. He is 4-for-11 since his recall from Triple-A Columbus.
There has been no revelation of an injury to the team's best hitter. But he has struggled in the series with just one hit in 12 at-bats.
The 24-year-old Duffey has been lights-out at the Double-A and Triple-A levels this season, compiling a 2.66 ERA and allowing just 118 hits and 30 walks in 132 innings with 117 strikeouts.
Nova has been solid in six outings this year with a 3-3 mark and 3.38 ERA. But he has yet to pitch more than 6 2/3 innings.
Moreno has been inconsistent in his four appearances this season and owns a 5.23 ERA. Pinder, who had been sent down just last week, has posted a 2.92 ERA in 11 games for the Yankees this season.
Puig was replaced in right field by Andre Ethier, who will bat fourth. Puig is batting .213 with three home runs and 12 RBI over his last 14 games.