The third-year receiver is off to a good start with respect to putting his drop-laden 2015 behind him, as he's looked like a much more consistent receiver throughout the first three weeks of the new campaign. Evans also has posted a 75 percent (3-for-4) success rate in the red zone, after hauling in only two of 13 targets (15.4 percent) inside the 20 last season. With a whopping 39 targets, touchdowns in each contest, and a solid 14.3 YPC to date, the 23-year-old seems primed for a standout campaign.
After exiting the Bucs' Week 2 tilt versus the Cardinals with is injury, Ayers missed all of practice last week, as well as the Week 3 loss to the Rams. The veteran defensive end's absence resulted in an uptick in William Gholston's tackle numbers and didn't seem to hinder Tampa's stalwart run defense, as they still managed to contain Todd Gurley to the tune of 3.2 YPC. If he logs another DNP on Thursday, Ayers will seemingly be on his way to missing another contest.
Vaccaro injured his ankle in Week 2's loss to the Giants, and subsequently missed the following game. He indicated his absence was more of a coaching decision, as he felt he could have played through it. The starting strong safety appears to be on track for a return Sunday.
Spruce has been out of action since Week 1 of the preseason due to a knee injury. His full participation at practice Wednesday seems to indicate he is trending toward making his season debut on Sunday. However, he is buried on the team's depth chart, so his opportunities to take the field will be limited.
Celek took over as the 49ers' starting tight end after Vance McDonald exited Week 3's contest with a hip injury. With McDonald McDonald unlikely to be available against the Cowboys on Sunday, Celek will likely get another crack at starting tight end as long as his back injury isn't of major concern. Keep tabs on Celek's progress as the week goes on, as he could be a nice streaming against a Cowboys' defense that has allowed 82 yards per game to tight ends this season.
The rookie returned to practice last week after dealing with a shoulder injury, but he has yet to take the field this season. He appears to be trending toward making his debut given his full participation in Wednesday's practice. His role figures to be limited however, as he is still behind Kenny Britt, Tavon Auston, and Brian Quick on the depth chart.
Gaines has yet to play this season due to a quadriceps injury, but appears on track to change that in Sunday's matchup with the Cardinals. The third-year cornerback figures to provide depth in the secondary when he returns.
Butler was seen in a walking boot at Wednesday's practice, and while he may hold snaps for Chandler Catanzaro on Sunday, the chances of him punting against the Rams seem slim. If Butler sits, the Cardinals will need to look elsewhere to delegate punting responsibilities.
Nkemdiche's full workload at practice would indicate that his ankle injury is largely healed at this point, even though it caused him to miss Week 3's tilt against the Bills. All signs point to him being able to go Sunday against the Rams.
Vannett has now been limited in two straight practices, which is a sign that he is making progress with his recovery from an ankle sprain. When he does return to game action, he will sit behind Jimmy Graham and Luke Willson at tight end and is unlikely to make any kind of fantasy impact.